Douglas B Stairs Selected Research

Delta Catenin

1/2021	Black raspberry restores the expression of the tumor suppressor p120ctn in the oral cavity of mice treated with the carcinogen dibenzo[a,l]pyrene diol epoxide.
1/2020	Loss of p120ctn causes EGFR-targeted therapy resistance and failure.
1/2019	E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions.
2/2018	NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation.
10/2017	p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC.
2/2016	Increasing diagnostic accuracy to grade dysplasia in Barrett's esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1.
1/2015	p120-catenin down-regulation and epidermal growth factor receptor overexpression results in a transformed epithelium that mimics esophageal squamous cell carcinoma.
4/2011	Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.

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Douglas B Stairs Research Topics

Disease

10	Neoplasms (Cancer) 01/2021 - 04/2007
3	Inflammation (Inflammations) 01/2021 - 01/2010
3	Squamous Cell Carcinoma of Head and Neck 01/2021 - 10/2017
2	Infections 01/2021 - 01/2010
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2021 - 11/2009
2	Esophageal Squamous Cell Carcinoma 02/2018 - 01/2015
2	Barrett Esophagus (Barrett's Esophagus) 02/2016 - 01/2008
2	Bile Reflux 09/2011 - 01/2010
1	Papilloma (Papillomatosis) 01/2021
1	Papillomavirus Infections 01/2021
1	Hyperplasia 01/2021
1	Leukemia 01/2021
1	Chromosomal Instability (Chromosome Stability) 01/2021
1	Acne Vulgaris 01/2019
1	Atopic Dermatitis (Atopic Eczema) 01/2019
1	Wounds and Injuries (Trauma) 01/2019
1	Hidradenitis Suppurativa 01/2019
1	Neoplasm Metastasis (Metastasis) 10/2017
1	Cysts 09/2011
1	Metaplasia 01/2010
1	Gastroesophageal Reflux (GERD) 01/2008
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 11/2007
1	Esophageal Neoplasms (Esophageal Cancer) 04/2007

Drug/Important Bio-Agent (IBA)

8	Delta CateninIBA 01/2021 - 04/2011
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2019
3	AcidsIBA 09/2011 - 01/2008
3	Transcription Factors (Transcription Factor)IBA 01/2010 - 01/2008
2	CarcinogensIBA 01/2021 - 01/2021
2	SmokeIBA 01/2021 - 01/2021
2	Biological ProductsIBA 01/2021 - 01/2020
2	ErbB Receptors (EGF Receptor)IBA 01/2015 - 11/2007
2	MucinsIBA 09/2011 - 01/2008
2	Keratins (Keratin)IBA 01/2008 - 11/2007
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Viral DNAIBA 01/2021
1	Environmental Pollutants (Pollutants, Environmental)IBA 01/2021
1	dibenzo(a,l)pyreneIBA 01/2021
1	Viral ProteinsIBA 01/2021
1	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 01/2021
1	dibenzo(a,l)pyrene diol epoxideIBA 01/2021
1	Cadherins (E-Cadherin)IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 02/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2011
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 04/2011
1	Macrophage Colony-Stimulating FactorIBA 04/2011
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 04/2011
1	DNA (Deoxyribonucleic Acid)IBA 11/2009
1	Bile Acids and Salts (Bile Acids)IBA 01/2008
1	Telomerase (Telomerase Reverse Transcriptase)IBA 11/2007
1	Insulin-Like Growth Factor Binding Protein 3IBA 04/2007
1	Caspase 3 (Caspase-3)IBA 04/2007